This Innovative Solutions Opening seeks solution summaries and proposals for projects addressing systemic challenges in healthcare and public health under the ARPA-H Resilient Systems Office mission. Proposals must be submitted via ARPA-H’s Solution Submission Portal, with a response deadline of March 6, 2029. [1][2][3]
Key points
Submissions must address systemic challenges in healthcare and public health. [1]
Proposals must be submitted through ARPA-H’s Solution Submission Portal. [2]
RSO_MO_ISO_AMEND_3.pdf9 ARPA-H-SOL-24-103 AMENDMENT 03 • The Proposer meets the eligibility requirements. • The proposal meets the submission requirements. • The proposal meets the content and formatting requirements in the attached bundle of attachments. • The Proposer’s concept has not already received funding or been selected for award negotiations for another funding opportunity (whether from ARPA-H or another government agency).
RSO_MO_ISO_AMEND_3.pdfProposals must be submitted through ARPA-H’s Solution Submission Portal.
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9 ARPA-H-SOL-24-103 AMENDMENT 03 • The Proposer meets the eligibility requirements. • The proposal meets the submission requirements. • The proposal meets the content and formatting requirements in the attached bundle of attachments. • The Proposer’s concept has not already received funding or been selected for award negotiations for another funding opportunity (whether from ARPA-H or another government agency).
Extracted from the official notice and archived solicitation files. Confirm controlling requirements in the source documents.
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This ISO seeks solution summary and proposal submissions for projects that fall within the scope of the ARPA-H mission Resilient Systems Office (RSO). RSO's interest areas will address systemic challenges across the healthcare and public health landscape by investing in cutting-edge technologies that address long-standing gaps in the quality, efficacy, and consistent availability of care. Solution summary submissions must be submitted to: https://solutions.arpa-h.gov Questions must be submitted to: https://solutions.arpa-h.gov/Ask-A-Question/ Proposal submission should be submitted to: https://solutions.arpa-h.gov/Submit-Proposal/ Amendment 3 is effective immediately; however, if an entity has previously submitted a solution summary and/or a proposal, the prior solicitation(s) will be followed for those submissions. If a solution summary is submitted; however, a proposal has not been submitted yet, the proposal will be evaluated in accordance with this amendment. The following updates were made to the proposal documents: 1) Administrative & National Policy Requirements Document Updated the instructions and references within the "Organizational Conflicts of Interest (OCI) Affirmations and Disclosure" section. Updated questions, instructions, and content within the "Research Security Disclosure" section. Updated the instructions and intellectual property data assertions charts within the "IP" section. This included providing definitions of rights categories (unlimited, government purpose, limited, and specially negotiated/other) and consolidating two data assertions charts into one to assist proposers more efficiently complete the document. Specifically, the "Non-Commercial" and "Commercial" tables were removed and replaced with the "Background IP and Data Assertions" table. Eliminated the "Software Component Standards" section. Updated the Human Subjects Research (HSR) table within the "HSR" section. Updated the Animal Subjects Research (ASR) table within the "ASR" section. Updated the questions and instructions within the "Biosecurity" section. 2) Cost Proposal Document (Word document) Updated the instructions within the "Level of Effort and Labor Costs" section. Added definitions for "burdened labor rate" and "fully burdened labor rate" to provide clarity for proposers when completing the document. Also added a statement to clarify that fully burdened labor rates are not used in the Cost Proposal Workbooks. Increased the threshold for proposers to provide supporting documentation with their proposal for planned materials and equipment purchases based on unit cost. The unit cost threshold was increased from $5,000 to $10,000. 3) Cost Proposal Workbooks (Excel spreadsheets) Updated instructions to clarify that ARPA-H will assume profit/fee is not applicable for proposals if proposers do not include profit/fee in the workbook. Updated the instructions for supporting documentation associated with planned materials and equipment purchases (based on the unit cost threshold increasing from $5,000 to $10,000). Completed administrative update to a tab
What changed
Nov 13, 2025 · 2 fields changed
DescriptionThis ISO seeks solution summary and proposal submissions for projects that fall within the scope of the ARPA-H mission Resilient Systems Office (RSO). RSO's interest areas will address systemic challenges across the healthcare and public health landscape by investing in cutting-edge technologies that address long-standing gaps in the quality, efficacy, and consistent availability of care. Solution summary submissions must be submitted to: https://solutions.arpa-h.gov Questions must be submitted to: https://solutions.arpa-h.gov/Ask-A-Question/ Proposal submission should be submitted to: https://solutions.arpa-h.gov/Submit-Proposal/ Amendment 3 is effective immediately; however, if an entity has previously submitted a solution summary and/or a proposal, the prior solicitation(s) will be followed for those submissions. If a solution summary is submitted; however, a proposal has not been submitted yet, the proposal will be evaluated in accordance with this amendment. The following updates were made to the proposal documents: 1) Administrative & National Policy Requirements Document Updated the instructions and references within the "Organizational Conflicts of Interest (OCI) Affirmations and Disclosure" section. Updated questions, instructions, and content within the "Research Security Disclosure" section. Updated the instructions and intellectual property data assertions charts within the "IP" section. This included providing definitions of rights categories (unlimited, government purpose, limited, and specially negotiated/other) and consolidating two data assertions charts into one to assist proposers more efficiently complete the document. Specifically, the "Non-Commercial" and "Commercial" tables were removed and replaced with the "Background IP and Data Assertions" table. Eliminated the "Software Component Standards" section. Updated the Human Subjects Research (HSR) table within the "HSR" section. Updated the Animal Subjects Research (ASR) table within the "ASR" section. Updated the questions and instructions within the "Biosecurity" section. 2) Cost Proposal Document (Word document) Updated the instructions within the "Level of Effort and Labor Costs" section. Added definitions for "burdened labor rate" and "fully burdened labor rate" to provide clarity for proposers when completing the document. Also added a statement to clarify that fully burdened labor rates are not used in the Cost Proposal Workbooks. Increased the threshold for proposers to provide supporting documentation with their proposal for planned materials and equipment purchases based on unit cost. The unit cost threshold was increased from $5,000 to $10,000. 3) Cost Proposal Workbooks (Excel spreadsheets) Updated instructions to clarify that ARPA-H will assume profit/fee is not applicable for proposals if proposers do not include profit/fee in the workbook. Updated the instructions for supporting documentation associated with planned materials and equipment purchases (based on the unit cost threshold increasing from $5,000 to $10,000).This ISO seeks solution summary and proposal submissions for projects that fall within the scope of the ARPA-H mission Resilient Systems Office (RSO). RSO's interest areas will address systemic challenges across the healthcare and public health landscape by investing in cutting-edge technologies that address long-standing gaps in the quality, efficacy, and consistent availability of care. Solution summary submissions must be submitted to: https://solutions.arpa-h.gov Questions must be submitted to: https://solutions.arpa-h.gov/Ask-A-Question/ Proposal submission should be submitted to: https://solutions.arpa-h.gov/Submit-Proposal/ Amendment 3 is effective immediately; however, if an entity has previously submitted a solution summary and/or a proposal, the prior solicitation(s) will be followed for those submissions. If a solution summary is submitted; however, a proposal has not been submitted yet, the proposal will be evaluated in accordance with this amendment. The following updates were made to the proposal documents: 1) Administrative & National Policy Requirements Document Updated the instructions and references within the "Organizational Conflicts of Interest (OCI) Affirmations and Disclosure" section. Updated questions, instructions, and content within the "Research Security Disclosure" section. Updated the instructions and intellectual property data assertions charts within the "IP" section. This included providing definitions of rights categories (unlimited, government purpose, limited, and specially negotiated/other) and consolidating two data assertions charts into one to assist proposers more efficiently complete the document. Specifically, the "Non-Commercial" and "Commercial" tables were removed and replaced with the "Background IP and Data Assertions" table. Eliminated the "Software Component Standards" section. Updated the Human Subjects Research (HSR) table within the "HSR" section. Updated the Animal Subjects Research (ASR) table within the "ASR" section. Updated the questions and instructions within the "Biosecurity" section. 2) Cost Proposal Document (Word document) Updated the instructions within the "Level of Effort and Labor Costs" section. Added definitions for "burdened labor rate" and "fully burdened labor rate" to provide clarity for proposers when completing the document. Also added a statement to clarify that fully burdened labor rates are not used in the Cost Proposal Workbooks. Increased the threshold for proposers to provide supporting documentation with their proposal for planned materials and equipment purchases based on unit cost. The unit cost threshold was increased from $5,000 to $10,000. 3) Cost Proposal Workbooks (Excel spreadsheets) Updated instructions to clarify that ARPA-H will assume profit/fee is not applicable for proposals if proposers do not include profit/fee in the workbook. Updated the instructions for supporting documentation associated with planned materials and equipment purchases (based on the unit cost threshold increasing from $5,000 to $10,000). Completed administrative update to a tabDocumentsNot previously reported3
Oct 14, 2025 · 1 field changed
DescriptionThis ISO seeks solution summary and proposal submissions for projects that fall within the scope of the ARPA-H mission Resilient Systems Office (RSO). RSO's interest areas will address systemic challenges across the healthcare and public health landscape by investing in cutting-edge technologies that address long-standing gaps in the quality, efficacy, and consistent availability of care. Solution summary submissions must be submitted to: https://solutions.arpa-h.gov Questions must be submitted to: https://solutions.arpa-h.gov/Ask-A-Question/ Proposal submission should be submitted to: https://solutions.arpa-h.gov/Submit-Proposal/ Amendment 2 is effective immediately; however, if an entity has previously submitted a solution summary and/or a proposal, the base solicitation will be followed for those submissions. If a solution summary is submitted; however, a proposal has not been submitted yet, the proposal will be evaluated in accordance with this amendment. The amendment: Updated solutions summary template; Updated bundle of attachments for other transactions (admin & national policy requirements document, cost proposal narrative, cost proposal workbook, task description document, and technical & management proposal) for proposal submissions; Removed cooperative agreements as a potential award instrument and removed bundle of attachments for cooperative agreements; Updated various sections of the ISO.This ISO seeks solution summary and proposal submissions for projects that fall within the scope of the ARPA-H mission Resilient Systems Office (RSO). RSO's interest areas will address systemic challenges across the healthcare and public health landscape by investing in cutting-edge technologies that address long-standing gaps in the quality, efficacy, and consistent availability of care. Solution summary submissions must be submitted to: https://solutions.arpa-h.gov Questions must be submitted to: https://solutions.arpa-h.gov/Ask-A-Question/ Proposal submission should be submitted to: https://solutions.arpa-h.gov/Submit-Proposal/ Amendment 3 is effective immediately; however, if an entity has previously submitted a solution summary and/or a proposal, the prior solicitation(s) will be followed for those submissions. If a solution summary is submitted; however, a proposal has not been submitted yet, the proposal will be evaluated in accordance with this amendment. The following updates were made to the proposal documents: 1) Administrative & National Policy Requirements Document Updated the instructions and references within the "Organizational Conflicts of Interest (OCI) Affirmations and Disclosure" section. Updated questions, instructions, and content within the "Research Security Disclosure" section. Updated the instructions and intellectual property data assertions charts within the "IP" section. This included providing definitions of rights categories (unlimited, government purpose, limited, and specially negotiated/other) and consolidating two data assertions charts into one to assist proposers more efficiently complete the document. Specifically, the "Non-Commercial" and "Commercial" tables were removed and replaced with the "Background IP and Data Assertions" table. Eliminated the "Software Component Standards" section. Updated the Human Subjects Research (HSR) table within the "HSR" section. Updated the Animal Subjects Research (ASR) table within the "ASR" section. Updated the questions and instructions within the "Biosecurity" section. 2) Cost Proposal Document (Word document) Updated the instructions within the "Level of Effort and Labor Costs" section. Added definitions for "burdened labor rate" and "fully burdened labor rate" to provide clarity for proposers when completing the document. Also added a statement to clarify that fully burdened labor rates are not used in the Cost Proposal Workbooks. Increased the threshold for proposers to provide supporting documentation with their proposal for planned materials and equipment purchases based on unit cost. The unit cost threshold was increased from $5,000 to $10,000. 3) Cost Proposal Workbooks (Excel spreadsheets) Updated instructions to clarify that ARPA-H will assume profit/fee is not applicable for proposals if proposers do not include profit/fee in the workbook. Updated the instructions for supporting documentation associated with planned materials and equipment purchases (based on the unit cost threshold increasing from $5,000 to $10,000).
Jun 6, 2025 · 4 fields changed
TitleOffice-Wide Innovative Solutions Opening for Resilient Systems Office (RSO)Resilient Systems Office (RSO) Mission Office Innovative Solutions Opening (ISO)Response deadline2029-03-04T04:59:00+00:002029-03-06T04:59:00+00:00Archive date2029-03-182029-03-20DescriptionThis ISO seeks solution summary and proposal submissions for projects that fall within the scope of the ARPA-H mission Resilient Systems Office (RSO). RSO's interest areas will address systemic challenges across the healthcare and public health landscape by investing in cutting-edge technologies that address long-standing gaps in the quality, efficacy, and consistent availability of care. Solution summary submissions must be submitted to: https://solutions.arpa-h.gov Questions must be submitted to: https://solutions.arpa-h.gov/Ask-A-Question/ Proposal submission should be submitted to: https://solutions.arpa-h.gov/Submit-Proposal/ Amendment 1 is effective immediately; however, if an entity has previously submitted a solution summary and/or a proposal, the base solicitation will be followed for those submissions. If a solution summary is submitted; however, a proposal has not been submitted yet, the proposal will be evaluated in accordance with this amendment. The amendment: Removes the option to submit a proposal through Grants.gov in Section 1 and Section 4.4. Removes the option for a proposer to submit a solution summary and proposal at the same time. Language is deleted in Section 2.2 and Section 5.1. Removes duplicative language about the type of eligible proposers in Section 3.1 because language is found in Section 2.2. Incorporates language in Section 3.2 to show "FFRDCs and government entities, including federal government employees, are not permitted to respond to this solicitation " and includes information on how handle unique proposal situations. Incorporates language in Section 3.5 to encourage submission of research ideas notwithstanding any potential ARPA-H award limitations. Incorporates language in Section 4.1 to expand on the reasoning for requiring solution summaries. Incorporates language in Section 4.4 to clarify required documents for other transaction and cooperative agreement proposal submissions. Extends the solicitation to be open until March 3, 2029. Removes time limiting language in Section 4.5. Includes language in Section 4.6 to show, "ARPA-H is responsible for handling submissions to the extent permitted under applicable federal law, including the Freedom of Information Act (FOIA)" and adds language in Section 5.5 to include FOIA. Removes the Section 4 "Security Information" language which only referenced Section 6.1. Clarifies in Section 5.2, the Task Description Document and the Research Description Document will not be evaluated as part of the proposal evaluation process. Updates Criterion 4 under Section 5.2 to include "Budget Risk Analysis" instead of "Price Realism". Includes requirements to comply with NIH's Genomic Data Sharing Policy if applicable, in Section 6.1 Incorporates requirements for sans serif fonts to be used for readability purposes in Appendix A. Incorporates administrative changes. Incorporates administrative changes and updates language under Section 10 in the Administrative & National Policy Requirements Document Template in both Cooperative Agreement and Other Transaction Bundle. Incorporates an updated Model Cooperative Agreement and Model OT in the Cooperative Agreement and Other Transaction Bundle.This ISO seeks solution summary and proposal submissions for projects that fall within the scope of the ARPA-H mission Resilient Systems Office (RSO). RSO's interest areas will address systemic challenges across the healthcare and public health landscape by investing in cutting-edge technologies that address long-standing gaps in the quality, efficacy, and consistent availability of care. Solution summary submissions must be submitted to: https://solutions.arpa-h.gov Questions must be submitted to: https://solutions.arpa-h.gov/Ask-A-Question/ Proposal submission should be submitted to: https://solutions.arpa-h.gov/Submit-Proposal/ Amendment 2 is effective immediately; however, if an entity has previously submitted a solution summary and/or a proposal, the base solicitation will be followed for those submissions. If a solution summary is submitted; however, a proposal has not been submitted yet, the proposal will be evaluated in accordance with this amendment. The amendment: Updated solutions summary template; Updated bundle of attachments for other transactions (admin & national policy requirements document, cost proposal narrative, cost proposal workbook, task description document, and technical & management proposal) for proposal submissions; Removed cooperative agreements as a potential award instrument and removed bundle of attachments for cooperative agreements; Updated various sections of the ISO.
Sep 25, 2024 · 3 fields changed
Response deadline2025-03-15T21:00:00+00:002029-03-04T04:59:00+00:00Archive date2025-03-302029-03-18DescriptionThis ISO seeks solution summary and proposal submissions for projects that fall within the scope of the ARPA-H mission Resilient Systems Office (RSO). RSO's interest areas will address systemic challenges across the healthcare and public health landscape by investing in cutting-edge technologies that address long-standing gaps in the quality, efficacy, and consistent availability of care. Solution summary submissions must be submitted to: https://solutions.arpa-h.gov Questions must be submitted to: https://solutions.arpa-h.gov/Ask-A-Question/ Proposal submission should be submitted to: https://solutions.arpa-h.gov/Submit-Proposal/ NOTE: Proposers' requesting a Cooperative Agreement are strongly encouraged to submit a proposals to the ARPA-H proposal link (https://solutions.arpa-h.gov/Submit-Proposal/); however, those proposals may be submitted to Grants.gov.This ISO seeks solution summary and proposal submissions for projects that fall within the scope of the ARPA-H mission Resilient Systems Office (RSO). RSO's interest areas will address systemic challenges across the healthcare and public health landscape by investing in cutting-edge technologies that address long-standing gaps in the quality, efficacy, and consistent availability of care. Solution summary submissions must be submitted to: https://solutions.arpa-h.gov Questions must be submitted to: https://solutions.arpa-h.gov/Ask-A-Question/ Proposal submission should be submitted to: https://solutions.arpa-h.gov/Submit-Proposal/ Amendment 1 is effective immediately; however, if an entity has previously submitted a solution summary and/or a proposal, the base solicitation will be followed for those submissions. If a solution summary is submitted; however, a proposal has not been submitted yet, the proposal will be evaluated in accordance with this amendment. The amendment: Removes the option to submit a proposal through Grants.gov in Section 1 and Section 4.4. Removes the option for a proposer to submit a solution summary and proposal at the same time. Language is deleted in Section 2.2 and Section 5.1. Removes duplicative language about the type of eligible proposers in Section 3.1 because language is found in Section 2.2. Incorporates language in Section 3.2 to show "FFRDCs and government entities, including federal government employees, are not permitted to respond to this solicitation " and includes information on how handle unique proposal situations. Incorporates language in Section 3.5 to encourage submission of research ideas notwithstanding any potential ARPA-H award limitations. Incorporates language in Section 4.1 to expand on the reasoning for requiring solution summaries. Incorporates language in Section 4.4 to clarify required documents for other transaction and cooperative agreement proposal submissions. Extends the solicitation to be open until March 3, 2029. Removes time limiting language in Section 4.5. Includes language in Section 4.6 to show, "ARPA-H is responsible for handling submissions to the extent permitted under applicable federal law, including the Freedom of Information Act (FOIA)" and adds language in Section 5.5 to include FOIA. Removes the Section 4 "Security Information" language which only referenced Section 6.1. Clarifies in Section 5.2, the Task Description Document and the Research Description Document will not be evaluated as part of the proposal evaluation process. Updates Criterion 4 under Section 5.2 to include "Budget Risk Analysis" instead of "Price Realism". Includes requirements to comply with NIH's Genomic Data Sharing Policy if applicable, in Section 6.1 Incorporates requirements for sans serif fonts to be used for readability purposes in Appendix A. Incorporates administrative changes. Incorporates administrative changes and updates language under Section 10 in the Administrative & National Policy Requirements Document Template in both Cooperative Agreement and Other Transaction Bundle. Incorporates an updated Model Cooperative Agreement and Model OT in the Cooperative Agreement and Other Transaction Bundle.
Notice history
Solicitation · LatestPosted Jan 8, 2026 · response deadline Mar 6, 2029, 4:59 AM UTC
SolicitationPosted Nov 13, 2025 · response deadline Mar 6, 2029, 4:59 AM UTC
SolicitationPosted Oct 14, 2025 · response deadline Mar 6, 2029, 4:59 AM UTC
SolicitationPosted Oct 14, 2025 · response deadline Mar 6, 2029, 4:59 AM UTC
SolicitationPosted Jun 6, 2025 · response deadline Mar 6, 2029, 4:59 AM UTC
SolicitationPosted Sep 25, 2024 · response deadline Mar 4, 2029, 4:59 AM UTC
SolicitationPosted Sep 25, 2024 · response deadline Mar 4, 2029, 4:59 AM UTC
SolicitationPosted May 2, 2024 · response deadline Mar 15, 2025, 9:00 PM UTC
SolicitationPosted Mar 14, 2024 · response deadline Mar 15, 2025, 9:00 PM UTC
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