This Innovative Solutions Opening (ISO) seeks solution summaries and proposals for projects aligning with the ARPA-H Health Science Futures (HSF) mission office, focusing on advancing healthcare technology. Submissions must be made through ARPA-H’s Solution Submission Portal, with a response deadline of March 6, 2029. [1][3][4]
Key points
ISO seeks solutions for HSF mission office projects. [1]
Proposals must be submitted via ARPA-H Solution Submission Portal. [3]
Additional details are in the Administrative & National Policy Requirements Document. [2]
Sources
HSF_MO_ISO_AMEND_3.pdf11 • The proposed concept is applicable to the ISO interest areas. • The Proposer meets the eligibility requirements. • The proposal meets the submission requirements. • The proposal meets the content and formatting requirements in the attached bundle of attachments. • The Proposer’s concept has not already received funding or been selected for award negotiations for another funding opportunity (whether from ARPA-H or another government agency).
HSF_MO_ISO_AMEND_3.pdfAdditional information can be found in the Administrative & National Policy Requirements Document.
HSF_MO_ISO_AMEND_3.pdfProposals must be submitted through ARPA-H’s Solution Submission Portal.
Generated from the public notice and source-backed solicitation passages. Confirm important requirements in the cited brief and official documents.
Public-source intelligence
Source-backed opportunity brief
7 citations · 6 sources
11 • The proposed concept is applicable to the ISO interest areas. • The Proposer meets the eligibility requirements. • The proposal meets the submission requirements. • The proposal meets the content and formatting requirements in the attached bundle of attachments. • The Proposer’s concept has not already received funding or been selected for award negotiations for another funding opportunity (whether from ARPA-H or another government agency).
Extracted from the official notice and archived solicitation files. Confirm controlling requirements in the source documents.
Notice information
Read full notice text
This ISO seeks solution summaries and proposal submissions for projects that fall within the general scope of the ARPA-H Health Science Futures (HSF) mission office. HSF expands what is technically possible by developing approaches that will remove the scientific and technological limitations that stymie progress towards the healthcare of the future. HSF supports cutting-edge, often disease-agnostic research programs that have the potential for translational real-world change. Solution summary submissions must be submitted to: https://solutions.arpa-h.gov Questions must be submitted to: https://solutions.arpa-h.gov/Ask-A-Question/ Proposal submission should be submitted to: https://solutions.arpa-h.gov/Submit-Proposal/ Amendment 3 is effective immediately; however, if an entity has previously submitted a solution summary and/or a proposal, the prior solicitation(s) will be followed for those submissions. If a solution summary is submitted; however, a proposal has not been submitted yet, the proposal will be evaluated in accordance with this amendment. The following updates were made to the proposal documents: 1) Administrative & National Policy Requirements Document Updated the instructions and references within the "Organizational Conflicts of Interest (OCI) Affirmations and Disclosure" section. Updated questions, instructions, and content within the "Research Security Disclosure" section. Updated the instructions and intellectual property data assertions charts within the "IP" section. This included providing definitions of rights categories (unlimited, government purpose, limited, and specially negotiated/other) and consolidating two data assertions charts into one to assist proposers more efficiently complete the document. Specifically, the "Non-Commercial" and "Commercial" tables were removed and replaced with the "Background IP and Data Assertions" table. Eliminated the "Software Component Standards" section. Updated the Human Subjects Research (HSR) table within the "HSR" section. Updated the Animal Subjects Research (ASR) table within the "ASR" section. Updated the questions and instructions within the "Biosecurity" section. 2) Cost Proposal Document (Word document) Updated the instructions within the "Level of Effort and Labor Costs" section. Added definitions for "burdened labor rate" and "fully burdened labor rate" to provide clarity for proposers when completing the document. Also added a statement to clarify that fully burdened labor rates are not used in the Cost Proposal Workbooks. Increased the threshold for proposers to provide supporting documentation with their proposal for planned materials and equipment purchases based on unit cost. The unit cost threshold was increased from $5,000 to $10,000. 3) Cost Proposal Workbooks (Excel spreadsheets) Updated instructions to clarify that ARPA-H will assume profit/fee is not applicable for proposals if proposers do not include profit/fee in the workbook. Updated the instructions for supporting documentation associated with planned materials and equipment purchases (based on the unit cost threshold increasing from $5,000 to $10,000). Completed administrative update to a tab
What changed
Nov 13, 2025 · 2 fields changed
DescriptionThis ISO seeks solution summaries and proposal submissions for projects that fall within the general scope of the ARPA-H Health Science Futures (HSF) mission office. HSF expands what is technically possible by developing approaches that will remove the scientific and technological limitations that stymie progress towards the healthcare of the future. HSF supports cutting-edge, often disease-agnostic research programs that have the potential for translational real-world change. Solution summary submissions must be submitted to: https://solutions.arpa-h.gov Questions must be submitted to: https://solutions.arpa-h.gov/Ask-A-Question/ Proposal submission should be submitted to: https://solutions.arpa-h.gov/Submit-Proposal/ Amendment 3 is effective immediately; however, if an entity has previously submitted a solution summary and/or a proposal, the prior solicitation(s) will be followed for those submissions. If a solution summary is submitted; however, a proposal has not been submitted yet, the proposal will be evaluated in accordance with this amendment. The following updates were made to the proposal documents: 1) Administrative & National Policy Requirements Document Updated the instructions and references within the "Organizational Conflicts of Interest (OCI) Affirmations and Disclosure" section. Updated questions, instructions, and content within the "Research Security Disclosure" section. Updated the instructions and intellectual property data assertions charts within the "IP" section. This included providing definitions of rights categories (unlimited, government purpose, limited, and specially negotiated/other) and consolidating two data assertions charts into one to assist proposers more efficiently complete the document. Specifically, the "Non-Commercial" and "Commercial" tables were removed and replaced with the "Background IP and Data Assertions" table. Eliminated the "Software Component Standards" section. Updated the Human Subjects Research (HSR) table within the "HSR" section. Updated the Animal Subjects Research (ASR) table within the "ASR" section. Updated the questions and instructions within the "Biosecurity" section. 2) Cost Proposal Document (Word document) Updated the instructions within the "Level of Effort and Labor Costs" section. Added definitions for "burdened labor rate" and "fully burdened labor rate" to provide clarity for proposers when completing the document. Also added a statement to clarify that fully burdened labor rates are not used in the Cost Proposal Workbooks. Increased the threshold for proposers to provide supporting documentation with their proposal for planned materials and equipment purchases based on unit cost. The unit cost threshold was increased from $5,000 to $10,000. 3) Cost Proposal Workbooks (Excel spreadsheets) Updated instructions to clarify that ARPA-H will assume profit/fee is not applicable for proposals if proposers do not include profit/fee in the workbook. Updated the instructions for supporting documentation associated with planned materials and equipment purchases (based on the unit cost threshold increasing from $5,000 to $10,000).This ISO seeks solution summaries and proposal submissions for projects that fall within the general scope of the ARPA-H Health Science Futures (HSF) mission office. HSF expands what is technically possible by developing approaches that will remove the scientific and technological limitations that stymie progress towards the healthcare of the future. HSF supports cutting-edge, often disease-agnostic research programs that have the potential for translational real-world change. Solution summary submissions must be submitted to: https://solutions.arpa-h.gov Questions must be submitted to: https://solutions.arpa-h.gov/Ask-A-Question/ Proposal submission should be submitted to: https://solutions.arpa-h.gov/Submit-Proposal/ Amendment 3 is effective immediately; however, if an entity has previously submitted a solution summary and/or a proposal, the prior solicitation(s) will be followed for those submissions. If a solution summary is submitted; however, a proposal has not been submitted yet, the proposal will be evaluated in accordance with this amendment. The following updates were made to the proposal documents: 1) Administrative & National Policy Requirements Document Updated the instructions and references within the "Organizational Conflicts of Interest (OCI) Affirmations and Disclosure" section. Updated questions, instructions, and content within the "Research Security Disclosure" section. Updated the instructions and intellectual property data assertions charts within the "IP" section. This included providing definitions of rights categories (unlimited, government purpose, limited, and specially negotiated/other) and consolidating two data assertions charts into one to assist proposers more efficiently complete the document. Specifically, the "Non-Commercial" and "Commercial" tables were removed and replaced with the "Background IP and Data Assertions" table. Eliminated the "Software Component Standards" section. Updated the Human Subjects Research (HSR) table within the "HSR" section. Updated the Animal Subjects Research (ASR) table within the "ASR" section. Updated the questions and instructions within the "Biosecurity" section. 2) Cost Proposal Document (Word document) Updated the instructions within the "Level of Effort and Labor Costs" section. Added definitions for "burdened labor rate" and "fully burdened labor rate" to provide clarity for proposers when completing the document. Also added a statement to clarify that fully burdened labor rates are not used in the Cost Proposal Workbooks. Increased the threshold for proposers to provide supporting documentation with their proposal for planned materials and equipment purchases based on unit cost. The unit cost threshold was increased from $5,000 to $10,000. 3) Cost Proposal Workbooks (Excel spreadsheets) Updated instructions to clarify that ARPA-H will assume profit/fee is not applicable for proposals if proposers do not include profit/fee in the workbook. Updated the instructions for supporting documentation associated with planned materials and equipment purchases (based on the unit cost threshold increasing from $5,000 to $10,000). Completed administrative update to a tabDocumentsNot previously reported3
Oct 14, 2025 · 1 field changed
DescriptionThis ISO seeks solution summaries and proposal submissions for projects that fall within the general scope of the ARPA-H Health Science Futures (HSF) mission office. HSF expands what is technically possible by developing approaches that will remove the scientific and technological limitations that stymie progress towards the healthcare of the future. HSF supports cutting-edge, often disease-agnostic research programs that have the potential for translational real-world change. Solution summary submissions must be submitted to: https://solutions.arpa-h.gov Questions must be submitted to: https://solutions.arpa-h.gov/Ask-A-Question/ Proposal submission should be submitted to: https://solutions.arpa-h.gov/Submit-Proposal/ Amendment 2 is effective immediately; however, if an entity has previously submitted a solution summary and/or a proposal, the base solicitation will be followed for those submissions. If a solution summary is submitted; however, a proposal has not been submitted yet, the proposal will be evaluated in accordance with this amendment. The amendment: Updated solutions summary template; Updated bundle of attachments for other transactions (admin & national policy requirements document, cost proposal narrative, cost proposal workbook, task description document, and technical & management proposal) for proposal submissions; Removed cooperative agreements as a potential award instrument and removed bundle of attachments for cooperative agreements; Updated various sections of the ISO.This ISO seeks solution summaries and proposal submissions for projects that fall within the general scope of the ARPA-H Health Science Futures (HSF) mission office. HSF expands what is technically possible by developing approaches that will remove the scientific and technological limitations that stymie progress towards the healthcare of the future. HSF supports cutting-edge, often disease-agnostic research programs that have the potential for translational real-world change. Solution summary submissions must be submitted to: https://solutions.arpa-h.gov Questions must be submitted to: https://solutions.arpa-h.gov/Ask-A-Question/ Proposal submission should be submitted to: https://solutions.arpa-h.gov/Submit-Proposal/ Amendment 3 is effective immediately; however, if an entity has previously submitted a solution summary and/or a proposal, the prior solicitation(s) will be followed for those submissions. If a solution summary is submitted; however, a proposal has not been submitted yet, the proposal will be evaluated in accordance with this amendment. The following updates were made to the proposal documents: 1) Administrative & National Policy Requirements Document Updated the instructions and references within the "Organizational Conflicts of Interest (OCI) Affirmations and Disclosure" section. Updated questions, instructions, and content within the "Research Security Disclosure" section. Updated the instructions and intellectual property data assertions charts within the "IP" section. This included providing definitions of rights categories (unlimited, government purpose, limited, and specially negotiated/other) and consolidating two data assertions charts into one to assist proposers more efficiently complete the document. Specifically, the "Non-Commercial" and "Commercial" tables were removed and replaced with the "Background IP and Data Assertions" table. Eliminated the "Software Component Standards" section. Updated the Human Subjects Research (HSR) table within the "HSR" section. Updated the Animal Subjects Research (ASR) table within the "ASR" section. Updated the questions and instructions within the "Biosecurity" section. 2) Cost Proposal Document (Word document) Updated the instructions within the "Level of Effort and Labor Costs" section. Added definitions for "burdened labor rate" and "fully burdened labor rate" to provide clarity for proposers when completing the document. Also added a statement to clarify that fully burdened labor rates are not used in the Cost Proposal Workbooks. Increased the threshold for proposers to provide supporting documentation with their proposal for planned materials and equipment purchases based on unit cost. The unit cost threshold was increased from $5,000 to $10,000. 3) Cost Proposal Workbooks (Excel spreadsheets) Updated instructions to clarify that ARPA-H will assume profit/fee is not applicable for proposals if proposers do not include profit/fee in the workbook. Updated the instructions for supporting documentation associated with planned materials and equipment purchases (based on the unit cost threshold increasing from $5,000 to $10,000).
Jun 6, 2025 · 4 fields changed
TitleOffice-Wide Innovative Solutions Opening for Health Science Futures (HSF)Health Science Futures (HSF) Mission Office Innovative Solutions Opening (ISO)Response deadline2029-03-04T04:59:00+00:002029-03-06T04:59:00+00:00Archive date2029-03-182029-03-20DescriptionThis ISO seeks solution summaries and proposal submissions for projects that fall within the general scope of the ARPA-H Health Science Futures (HSF) mission office. HSF expands what is technically possible by developing approaches that will remove the scientific and technological limitations that stymie progress towards the healthcare of the future. HSF supports cutting-edge, often disease-agnostic research programs that have the potential for translational real-world change. Solution summary submissions must be submitted to: https://solutions.arpa-h.gov Questions must be submitted to: https://solutions.arpa-h.gov/Ask-A-Question/ Proposal submission should be submitted to: https://solutions.arpa-h.gov/Submit-Proposal/ Amendment 1 is effective immediately; however, if an entity has previously submitted a solution summary and/or a proposal, the base solicitation will be followed for those submissions. If a solution summary is submitted; however, a proposal has not been submitted yet, the proposal will be evaluated in accordance with this amendment. The amendment: Removes the option to submit a proposal through Grants.gov in Section 1 and Section 4.4. Removes the option for a proposer to submit a solution summary and proposal at the same time. Language is deleted in Section 2.2 and Section 5.1. Removes duplicative language about the type of eligible proposers in Section 3.1 because language is found in Section 2.2. Incorporates language in Section 3.2 to show "FFRDCs and government entities, including federal government employees, are not permitted to respond to this solicitation " and includes information on how handle unique proposal situations. Incorporates language in Section 3.5 to encourage submission of research ideas notwithstanding any potential ARPA-H award limitations. Incorporates language in Section 4.1 to expand on the reasoning for requiring solution summaries. Incorporates language in Section 4.4 to clarify required documents for other transaction and cooperative agreement proposal submissions. Extends the solicitation to be open until March 3, 2029. Removes time limiting language in Section 4.5. Includes language in Section 4.6 to show, "ARPA-H is responsible for handling submissions to the extent permitted under applicable federal law, including the Freedom of Information Act (FOIA)" and adds language in Section 5.5 to include FOIA. Removes the Section 4 "Security Information" language which only referenced Section 6.1. Clarifies in Section 5.2, the Task Description Document and the Research Description Document will not be evaluated as part of the proposal evaluation process. Updates Criterion 4 under Section 5.2 to include "Budget Risk Analysis" instead of "Price Realism". Includes requirements to comply with NIH's Genomic Data Sharing Policy if applicable, in Section 6.1 Incorporates requirements for sans serif fonts to be used for readability purposes in Appendix A. Incorporates administrative changes. Incorporates administrative changes and updates language under Section 10 in the Administrative & National Policy Requirements Document Template in both Cooperative Agreement and Other Transaction Bundle. Incorporates an updated to the Model Cooperative Agreement and Model OT in the Cooperative Agreement and Other Transaction Bundle.This ISO seeks solution summaries and proposal submissions for projects that fall within the general scope of the ARPA-H Health Science Futures (HSF) mission office. HSF expands what is technically possible by developing approaches that will remove the scientific and technological limitations that stymie progress towards the healthcare of the future. HSF supports cutting-edge, often disease-agnostic research programs that have the potential for translational real-world change. Solution summary submissions must be submitted to: https://solutions.arpa-h.gov Questions must be submitted to: https://solutions.arpa-h.gov/Ask-A-Question/ Proposal submission should be submitted to: https://solutions.arpa-h.gov/Submit-Proposal/ Amendment 2 is effective immediately; however, if an entity has previously submitted a solution summary and/or a proposal, the base solicitation will be followed for those submissions. If a solution summary is submitted; however, a proposal has not been submitted yet, the proposal will be evaluated in accordance with this amendment. The amendment: Updated solutions summary template; Updated bundle of attachments for other transactions (admin & national policy requirements document, cost proposal narrative, cost proposal workbook, task description document, and technical & management proposal) for proposal submissions; Removed cooperative agreements as a potential award instrument and removed bundle of attachments for cooperative agreements; Updated various sections of the ISO.
Sep 25, 2024 · 3 fields changed
Response deadline2025-03-15T21:00:00+00:002029-03-04T04:59:00+00:00Archive date2025-03-302029-03-18DescriptionThis ISO seeks solution summaries and proposal submissions for projects that fall within the general scope of the ARPA-H Health Science Futures (HSF) mission office. HSF expands what is technically possible by developing approaches that will remove the scientific and technological limitations that stymie progress towards the healthcare of the future. HSF supports cutting-edge, often disease-agnostic research programs that have the potential for translational real-world change. Solution summary submissions must be submitted to: https://solutions.arpa-h.gov Questions must be submitted to: https://solutions.arpa-h.gov/Ask-A-Question/ Proposal submission should be submitted to: https://solutions.arpa-h.gov/Submit-Proposal/ NOTE: Proposers' requesting a Cooperative Agreement are strongly encouraged to submit a proposals to the ARPA-H proposal link (https://solutions.arpa-h.gov/Submit-Proposal/); however, those proposals may be submitted to Grants.gov.This ISO seeks solution summaries and proposal submissions for projects that fall within the general scope of the ARPA-H Health Science Futures (HSF) mission office. HSF expands what is technically possible by developing approaches that will remove the scientific and technological limitations that stymie progress towards the healthcare of the future. HSF supports cutting-edge, often disease-agnostic research programs that have the potential for translational real-world change. Solution summary submissions must be submitted to: https://solutions.arpa-h.gov Questions must be submitted to: https://solutions.arpa-h.gov/Ask-A-Question/ Proposal submission should be submitted to: https://solutions.arpa-h.gov/Submit-Proposal/ Amendment 1 is effective immediately; however, if an entity has previously submitted a solution summary and/or a proposal, the base solicitation will be followed for those submissions. If a solution summary is submitted; however, a proposal has not been submitted yet, the proposal will be evaluated in accordance with this amendment. The amendment: Removes the option to submit a proposal through Grants.gov in Section 1 and Section 4.4. Removes the option for a proposer to submit a solution summary and proposal at the same time. Language is deleted in Section 2.2 and Section 5.1. Removes duplicative language about the type of eligible proposers in Section 3.1 because language is found in Section 2.2. Incorporates language in Section 3.2 to show "FFRDCs and government entities, including federal government employees, are not permitted to respond to this solicitation " and includes information on how handle unique proposal situations. Incorporates language in Section 3.5 to encourage submission of research ideas notwithstanding any potential ARPA-H award limitations. Incorporates language in Section 4.1 to expand on the reasoning for requiring solution summaries. Incorporates language in Section 4.4 to clarify required documents for other transaction and cooperative agreement proposal submissions. Extends the solicitation to be open until March 3, 2029. Removes time limiting language in Section 4.5. Includes language in Section 4.6 to show, "ARPA-H is responsible for handling submissions to the extent permitted under applicable federal law, including the Freedom of Information Act (FOIA)" and adds language in Section 5.5 to include FOIA. Removes the Section 4 "Security Information" language which only referenced Section 6.1. Clarifies in Section 5.2, the Task Description Document and the Research Description Document will not be evaluated as part of the proposal evaluation process. Updates Criterion 4 under Section 5.2 to include "Budget Risk Analysis" instead of "Price Realism". Includes requirements to comply with NIH's Genomic Data Sharing Policy if applicable, in Section 6.1 Incorporates requirements for sans serif fonts to be used for readability purposes in Appendix A. Incorporates administrative changes. Incorporates administrative changes and updates language under Section 10 in the Administrative & National Policy Requirements Document Template in both Cooperative Agreement and Other Transaction Bundle. Incorporates an updated to the Model Cooperative Agreement and Model OT in the Cooperative Agreement and Other Transaction Bundle.
Mar 14, 2024 · 5 fields changed
TitleOffice-Wide Innovative Solutions OpeningOffice-Wide Innovative Solutions Opening for Health Science Futures (HSF)Notice typePresolicitationSolicitationResponse deadline2024-03-14T12:00:00+00:002025-03-15T21:00:00+00:00Archive date2024-03-292025-03-30DescriptionARPA-H is moving from an Agency wide Broad Agency Announcement (BAA), specifically the Open-Office BAA (75N99223S0001), to individual Office-wide solicitations. The Office-wide ISO is just one of several Office solicitations. Thus, each ISO has a targeted area of interest, may request submission of abstracts and/or proposals and will contain instructions informing potential performers how to properly submit a responsive abstract and/or proposal against the appropriate solicitation. Further, ARPA-H will leverage its broad acquisition authorities to create a fair and efficient process to solicit, evaluate, and select revolutionary ideas to achieve better health outcomes for all Americans. The Office-wide ISOs will award Other Transactions and Cooperative Agreements; therefore, the Federal Acquisition Regulations (FAR) is not applicable to Office-wide solicitation nor subsequent awards. This announcement includes DRAFT Office-wide ISOs for each ARPA-H Mission Office (HSF, PHO, RSO and SSO). Please note, abstract and proposal responses shall not be submitted against these DRAFT solicitations; thus, if an abstract or proposal is received against the DRAFT solicitations, the abstract and/or proposal will be discarded. Questions regarding the DRAFT solicitations MUST be submitted to https://solutions.arpa-h.gov/Ask-A-Question/. Questions sent directly to Mission Office Directors, Program Managers and/or additional ARPA-H personnel will be disgarded.This ISO seeks solution summaries and proposal submissions for projects that fall within the general scope of the ARPA-H Health Science Futures (HSF) mission office. HSF expands what is technically possible by developing approaches that will remove the scientific and technological limitations that stymie progress towards the healthcare of the future. HSF supports cutting-edge, often disease-agnostic research programs that have the potential for translational real-world change. Solution summary submissions must be submitted to: https://solutions.arpa-h.gov Questions must be submitted to: https://solutions.arpa-h.gov/Ask-A-Question/ Proposal submission should be submitted to: https://solutions.arpa-h.gov/Submit-Proposal/ NOTE: Proposers' requesting a Cooperative Agreement are strongly encouraged to submit a proposals to the ARPA-H proposal link (https://solutions.arpa-h.gov/Submit-Proposal/); however, those proposals may be submitted to Grants.gov.
Notice history
Solicitation · LatestPosted Jan 8, 2026 · response deadline Mar 6, 2029, 4:59 AM UTC
SolicitationPosted Nov 13, 2025 · response deadline Mar 6, 2029, 4:59 AM UTC
SolicitationPosted Oct 14, 2025 · response deadline Mar 6, 2029, 4:59 AM UTC
SolicitationPosted Oct 14, 2025 · response deadline Mar 6, 2029, 4:59 AM UTC
SolicitationPosted Jun 6, 2025 · response deadline Mar 6, 2029, 4:59 AM UTC
SolicitationPosted Sep 25, 2024 · response deadline Mar 4, 2029, 4:59 AM UTC
SolicitationPosted Mar 14, 2024 · response deadline Mar 15, 2025, 9:00 PM UTC
PresolicitationPosted Feb 28, 2024 · response deadline Mar 14, 2024, 12:00 PM UTC
Attachments
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