This ARPA-H solicitation seeks innovative solutions for stabilizing regenerative tissues and organs, focusing on temperature-flexible storage for complex biologics. Solutions can involve AI, new materials, or biological interventions to overcome current storage roadblocks. [2][1]
Key points
Goal is to unlock temperature-flexible storage for complex biologics. [1]
Strategies reducing reliance on strictly controlled temperature zones are preferred. [1]
Watch items
Solution Video submission deadline extended to August 12, 2026. [1]
Full Proposal submission deadline is September 17, 2026 for intake Group 1. [1]
Sources
ARPA-H-SOL-26-144_TIGAR+ISO+-+Amendment+4.pdfAPPENDIX A: Program and Technical Description APPENDIX B.0: Solution Video Format and Instructions APPENDIX B.1: Template for Supplemental Slides APPENDIX C.0: Full Proposal Format and Instructions APPENDIX C.1: Technical and Management Proposal APPENDIX C.2: Cost Proposal APPENDIX C.3: Cost Proposal Workbook APPENDIX C.4: Admin National Policy Requirements Document Additional resources: TIGAR Exploratory Topic Video: https://www.youtube.com/watch-v=cZs1DQPftGw APPENDIX D: Draft OT Agreement (available at https://arpah.gov/explore-funding/submission- resources-and-FAQs) 3 INNOVATIVE SOLUTIONS OPENING (ISO) SUMMARY INFORMATION FEDERAL AGENCY: Advanced Research Projects Agency for Health (ARPA
ARPA-H-SOL-26-144_TIGAR+ISO+-+Amendment+4.pdfAlthough potential proposers may submit a Full Proposal regardless of the feedback provided in response to a Solution Video submission, ARPA-H Solution Video feedback is provided to ensure that potential proposers are making an informed decision on the investment of time and resources toward a Full Proposal.
Generated from the public notice and source-backed solicitation passages. Confirm important requirements in the cited brief and official documents.
Public-source intelligence
Source-backed opportunity brief
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APPENDIX A: Program and Technical Description APPENDIX B.0: Solution Video Format and Instructions APPENDIX B.1: Template for Supplemental Slides APPENDIX C.0: Full Proposal Format and Instructions APPENDIX C.1: Technical and Management Proposal APPENDIX C.2: Cost Proposal APPENDIX C.3: Cost Proposal Workbook APPENDIX C.4: Admin National Policy Requirements Document Additional resources: TIGAR Exploratory Topic Video: https://www.youtube.com/watch-v=cZs1DQPftGw APPENDIX D: Draft OT Agreement (available at https://arpah.gov/explore-funding/submission- resources-and-FAQs) 3 INNOVATIVE SOLUTIONS OPENING (ISO) SUMMARY INFORMATION FEDERAL AGENCY: Advanced Research Projects Agency for Health (ARPA-H) EFFORT TITLE: Technology InteGrator and AcceleratoR (TIGAR) ANNOUNCEMENT TYPE: Innovative Solutions Opening (ISO) ISO NUMBER: ARPA-H-SOL-26-144 ISO CONTACT: TIGAR@arpa-h.gov ANTICIPATED AWARD(S): Multiple Other Transaction (OTs) Agreements For this solicitation, ARPA-H will only accept prime/subcontractor teaming arrangements and will not accept multi-party teaming arrangements.
Although potential proposers may submit a Full Proposal regardless of the feedback provided in response to a Solution Video submission, ARPA-H Solution Video feedback is provided to ensure that potential proposers are making an informed decision on the investment of time and resources toward a Full Proposal.
Extracted from the official notice and archived solicitation files. Confirm controlling requirements in the source documents.
Notice information
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Amendment 4 The ISO was updated to extend the Solution Video submission deadline to August 12, 2026 and the Full Proposal submission deadline to September 17, 2026 for intake Group 1. See page 3 of the full text ISO for more information. Amendment 3 (1) Appendix B was updated to remove track changes (2) Appendix C4 was updated to remove an erroneous comment. Amendment 2 (1) Instructions on how to submit a Solution Video were added to the ISO (see pages 7-8). (2) Information related to the Video Captions file was added to Appendix B.0 (Solution Video Format and Instructions). (3) The instructions in Appendix B.1 (Template for Supplemental Slides) were simplified, and a Cost Summary slide was added (see Slide 7). (4) Appendix C.3 was updated to reference "Phase" rather than "Year" for clarity. (5) The Administation and National Policy document in Appendix C.4 was replaced with an updated document. Amendment 1 The ISO was updated with the new webinar and webinar registration dates. Effort Description: TIGAR Exploratory Topic will forge entirely new paths to stabilizing regenerative tissues and organs by seeding the development of enabling technologies that can unlock temperature-flexible storage in increasingly larger and more complex biological systems. Solutions may involve any combination of new materials, artificial intelligence/machine learning, high-throughput screening methods, biological interventions, devices, processing methods, analytical technology, and packaging approaches that can overcome current roadblocks and yield a leap in the ability to store and distribute complex biologics, without introducing high cost or complexity. Strategies that reduce reliance on strictly controlled temperature zones and can ensure safe storage in a range of environmental conditions are preferred. While long-term temperature-flexible storage is ideal, any advance that removes logistical hurdles or establishes shelf-life stability at easy to maintain temperatures (preferably non-cryogenic) will be considered. Innovations at the cellular level without a strategy for deployment in thick tissues will not be considered. Please ensure to follow this opportunity for any updates. For more information on the TIGAR Exploratory Topic visit: https://arpa-h.gov/explore-funding/initiatives-and-sprints/tigar For information on Proposer's Day details and registration information, please see Special Notice ARPA-H-SN-26-142
What changed
Jul 13, 2026 · 1 field changed
DescriptionAmendment 3 (1) Appendix B was updated to remove track changes (2) Appendix C4 was updated to remove an erroneous comment. Amendment 2 (1) Instructions on how to submit a Solution Video were added to the ISO (see pages 7-8). (2) Information related to the Video Captions file was added to Appendix B.0 (Solution Video Format and Instructions). (3) The instructions in Appendix B.1 (Template for Supplemental Slides) were simplified, and a Cost Summary slide was added (see Slide 7). (4) Appendix C.3 was updated to reference "Phase" rather than "Year" for clarity. (5) The Administation and National Policy document in Appendix C.4 was replaced with an updated document. Amendment 1 The ISO was updated with the new webinar and webinar registration dates. Effort Description: TIGAR Exploratory Topic will forge entirely new paths to stabilizing regenerative tissues and organs by seeding the development of enabling technologies that can unlock temperature-flexible storage in increasingly larger and more complex biological systems. Solutions may involve any combination of new materials, artificial intelligence/machine learning, high-throughput screening methods, biological interventions, devices, processing methods, analytical technology, and packaging approaches that can overcome current roadblocks and yield a leap in the ability to store and distribute complex biologics, without introducing high cost or complexity. Strategies that reduce reliance on strictly controlled temperature zones and can ensure safe storage in a range of environmental conditions are preferred. While long-term temperature-flexible storage is ideal, any advance that removes logistical hurdles or establishes shelf-life stability at easy to maintain temperatures (preferably non-cryogenic) will be considered. Innovations at the cellular level without a strategy for deployment in thick tissues will not be considered. Please ensure to follow this opportunity for any updates. For more information on the TIGAR Exploratory Topic visit: https://arpa-h.gov/explore-funding/initiatives-and-sprints/tigar For information on Proposer's Day details and registration information, please see Special Notice ARPA-H-SN-26-142Amendment 4 The ISO was updated to extend the Solution Video submission deadline to August 12, 2026 and the Full Proposal submission deadline to September 17, 2026 for intake Group 1. See page 3 of the full text ISO for more information. Amendment 3 (1) Appendix B was updated to remove track changes (2) Appendix C4 was updated to remove an erroneous comment. Amendment 2 (1) Instructions on how to submit a Solution Video were added to the ISO (see pages 7-8). (2) Information related to the Video Captions file was added to Appendix B.0 (Solution Video Format and Instructions). (3) The instructions in Appendix B.1 (Template for Supplemental Slides) were simplified, and a Cost Summary slide was added (see Slide 7). (4) Appendix C.3 was updated to reference "Phase" rather than "Year" for clarity. (5) The Administation and National Policy document in Appendix C.4 was replaced with an updated document. Amendment 1 The ISO was updated with the new webinar and webinar registration dates. Effort Description: TIGAR Exploratory Topic will forge entirely new paths to stabilizing regenerative tissues and organs by seeding the development of enabling technologies that can unlock temperature-flexible storage in increasingly larger and more complex biological systems. Solutions may involve any combination of new materials, artificial intelligence/machine learning, high-throughput screening methods, biological interventions, devices, processing methods, analytical technology, and packaging approaches that can overcome current roadblocks and yield a leap in the ability to store and distribute complex biologics, without introducing high cost or complexity. Strategies that reduce reliance on strictly controlled temperature zones and can ensure safe storage in a range of environmental conditions are preferred. While long-term temperature-flexible storage is ideal, any advance that removes logistical hurdles or establishes shelf-life stability at easy to maintain temperatures (preferably non-cryogenic) will be considered. Innovations at the cellular level without a strategy for deployment in thick tissues will not be considered. Please ensure to follow this opportunity for any updates. For more information on the TIGAR Exploratory Topic visit: https://arpa-h.gov/explore-funding/initiatives-and-sprints/tigar For information on Proposer's Day details and registration information, please see Special Notice ARPA-H-SN-26-142
DescriptionAmendment 2 (1) Instructions on how to submit a Solution Video were added to the ISO (see pages 7-8). (2) Information related to the Video Captions file was added to Appendix B.0 (Solution Video Format and Instructions). (3) The instructions in Appendix B.1 (Template for Supplemental Slides) were simplified, and a Cost Summary slide was added (see Slide 7). (4) Appendix C.3 was updated to reference "Phase" rather than "Year" for clarity. (5) The Administation and National Policy document in Appendix C.4 was replaced with an updated document. Amendment 1 The ISO was updated with the new webinar and webinar registration dates. Effort Description: TIGAR Exploratory Topic will forge entirely new paths to stabilizing regenerative tissues and organs by seeding the development of enabling technologies that can unlock temperature-flexible storage in increasingly larger and more complex biological systems. Solutions may involve any combination of new materials, artificial intelligence/machine learning, high-throughput screening methods, biological interventions, devices, processing methods, analytical technology, and packaging approaches that can overcome current roadblocks and yield a leap in the ability to store and distribute complex biologics, without introducing high cost or complexity. Strategies that reduce reliance on strictly controlled temperature zones and can ensure safe storage in a range of environmental conditions are preferred. While long-term temperature-flexible storage is ideal, any advance that removes logistical hurdles or establishes shelf-life stability at easy to maintain temperatures (preferably non-cryogenic) will be considered. Innovations at the cellular level without a strategy for deployment in thick tissues will not be considered. Please ensure to follow this opportunity for any updates. For more information on the TIGAR Exploratory Topic visit: https://arpa-h.gov/explore-funding/initiatives-and-sprints/tigar For information on Proposer's Day details and registration information, please see Special Notice ARPA-H-SN-26-142Amendment 3 (1) Appendix B was updated to remove track changes (2) Appendix C4 was updated to remove an erroneous comment. Amendment 2 (1) Instructions on how to submit a Solution Video were added to the ISO (see pages 7-8). (2) Information related to the Video Captions file was added to Appendix B.0 (Solution Video Format and Instructions). (3) The instructions in Appendix B.1 (Template for Supplemental Slides) were simplified, and a Cost Summary slide was added (see Slide 7). (4) Appendix C.3 was updated to reference "Phase" rather than "Year" for clarity. (5) The Administation and National Policy document in Appendix C.4 was replaced with an updated document. Amendment 1 The ISO was updated with the new webinar and webinar registration dates. Effort Description: TIGAR Exploratory Topic will forge entirely new paths to stabilizing regenerative tissues and organs by seeding the development of enabling technologies that can unlock temperature-flexible storage in increasingly larger and more complex biological systems. Solutions may involve any combination of new materials, artificial intelligence/machine learning, high-throughput screening methods, biological interventions, devices, processing methods, analytical technology, and packaging approaches that can overcome current roadblocks and yield a leap in the ability to store and distribute complex biologics, without introducing high cost or complexity. Strategies that reduce reliance on strictly controlled temperature zones and can ensure safe storage in a range of environmental conditions are preferred. While long-term temperature-flexible storage is ideal, any advance that removes logistical hurdles or establishes shelf-life stability at easy to maintain temperatures (preferably non-cryogenic) will be considered. Innovations at the cellular level without a strategy for deployment in thick tissues will not be considered. Please ensure to follow this opportunity for any updates. For more information on the TIGAR Exploratory Topic visit: https://arpa-h.gov/explore-funding/initiatives-and-sprints/tigar For information on Proposer's Day details and registration information, please see Special Notice ARPA-H-SN-26-142Documents52
May 14, 2026 · 2 fields changed
DescriptionAmendment 1 The ISO was updated with the new webinar and webinar registration dates. Effort Description: TIGAR Exploratory Topic will forge entirely new paths to stabilizing regenerative tissues and organs by seeding the development of enabling technologies that can unlock temperature-flexible storage in increasingly larger and more complex biological systems. Solutions may involve any combination of new materials, artificial intelligence/machine learning, high-throughput screening methods, biological interventions, devices, processing methods, analytical technology, and packaging approaches that can overcome current roadblocks and yield a leap in the ability to store and distribute complex biologics, without introducing high cost or complexity. Strategies that reduce reliance on strictly controlled temperature zones and can ensure safe storage in a range of environmental conditions are preferred. While long-term temperature-flexible storage is ideal, any advance that removes logistical hurdles or establishes shelf-life stability at easy to maintain temperatures (preferably non-cryogenic) will be considered. Innovations at the cellular level without a strategy for deployment in thick tissues will not be considered. Please ensure to follow this opportunity for any updates. For more information on the TIGAR Exploratory Topic visit: https://arpa-h.gov/explore-funding/initiatives-and-sprints/tigar For information on Proposer's Day details and registration information, please see Special Notice ARPA-H-SN-26-142Amendment 2 (1) Instructions on how to submit a Solution Video were added to the ISO (see pages 7-8). (2) Information related to the Video Captions file was added to Appendix B.0 (Solution Video Format and Instructions). (3) The instructions in Appendix B.1 (Template for Supplemental Slides) were simplified, and a Cost Summary slide was added (see Slide 7). (4) Appendix C.3 was updated to reference "Phase" rather than "Year" for clarity. (5) The Administation and National Policy document in Appendix C.4 was replaced with an updated document. Amendment 1 The ISO was updated with the new webinar and webinar registration dates. Effort Description: TIGAR Exploratory Topic will forge entirely new paths to stabilizing regenerative tissues and organs by seeding the development of enabling technologies that can unlock temperature-flexible storage in increasingly larger and more complex biological systems. Solutions may involve any combination of new materials, artificial intelligence/machine learning, high-throughput screening methods, biological interventions, devices, processing methods, analytical technology, and packaging approaches that can overcome current roadblocks and yield a leap in the ability to store and distribute complex biologics, without introducing high cost or complexity. Strategies that reduce reliance on strictly controlled temperature zones and can ensure safe storage in a range of environmental conditions are preferred. While long-term temperature-flexible storage is ideal, any advance that removes logistical hurdles or establishes shelf-life stability at easy to maintain temperatures (preferably non-cryogenic) will be considered. Innovations at the cellular level without a strategy for deployment in thick tissues will not be considered. Please ensure to follow this opportunity for any updates. For more information on the TIGAR Exploratory Topic visit: https://arpa-h.gov/explore-funding/initiatives-and-sprints/tigar For information on Proposer's Day details and registration information, please see Special Notice ARPA-H-SN-26-142Documents35
Apr 24, 2026 · 2 fields changed
DescriptionEffort Description: TIGAR Exploratory Topic will forge entirely new paths to stabilizing regenerative tissues and organs by seeding the development of enabling technologies that can unlock temperature-flexible storage in increasingly larger and more complex biological systems. Solutions may involve any combination of new materials, artificial intelligence/machine learning, high-throughput screening methods, biological interventions, devices, processing methods, analytical technology, and packaging approaches that can overcome current roadblocks and yield a leap in the ability to store and distribute complex biologics, without introducing high cost or complexity. Strategies that reduce reliance on strictly controlled temperature zones and can ensure safe storage in a range of environmental conditions are preferred. While long-term temperature-flexible storage is ideal, any advance that removes logistical hurdles or establishes shelf-life stability at easy to maintain temperatures (preferably non-cryogenic) will be considered. Innovations at the cellular level without a strategy for deployment in thick tissues will not be considered. Please ensure to follow this opportunity for any updates. For more information on the TIGAR Exploratory Topic visit: https://arpa-h.gov/explore-funding/initiatives-and-sprints/tigar For information on Proposer's Day details and registration information, please see Special Notice ARPA-H-SN-26-142Amendment 1 The ISO was updated with the new webinar and webinar registration dates. Effort Description: TIGAR Exploratory Topic will forge entirely new paths to stabilizing regenerative tissues and organs by seeding the development of enabling technologies that can unlock temperature-flexible storage in increasingly larger and more complex biological systems. Solutions may involve any combination of new materials, artificial intelligence/machine learning, high-throughput screening methods, biological interventions, devices, processing methods, analytical technology, and packaging approaches that can overcome current roadblocks and yield a leap in the ability to store and distribute complex biologics, without introducing high cost or complexity. Strategies that reduce reliance on strictly controlled temperature zones and can ensure safe storage in a range of environmental conditions are preferred. While long-term temperature-flexible storage is ideal, any advance that removes logistical hurdles or establishes shelf-life stability at easy to maintain temperatures (preferably non-cryogenic) will be considered. Innovations at the cellular level without a strategy for deployment in thick tissues will not be considered. Please ensure to follow this opportunity for any updates. For more information on the TIGAR Exploratory Topic visit: https://arpa-h.gov/explore-funding/initiatives-and-sprints/tigar For information on Proposer's Day details and registration information, please see Special Notice ARPA-H-SN-26-142Documents13
Notice history
Solicitation · LatestPosted Jul 13, 2026 · response deadline Dec 8, 2026, 10:00 PM UTC
SolicitationPosted Jul 6, 2026 · response deadline Dec 8, 2026, 10:00 PM UTC
SolicitationPosted Jul 6, 2026 · response deadline Jun 8, 2026, 9:00 PM UTC
SolicitationPosted Jun 1, 2026 · response deadline Jun 8, 2026, 9:00 PM UTC
SolicitationPosted May 14, 2026 · response deadline Jun 8, 2026, 9:00 PM UTC
SolicitationPosted Apr 24, 2026 · response deadline Jun 8, 2026, 9:00 PM UTC
SolicitationPosted Apr 22, 2026 · response deadline Jun 8, 2026, 9:00 PM UTC
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