This solicitation supports the Brain Repair of Any Injured Neural Structure (BRAINS) Exploratory Topic program, anticipating multiple Other Transaction awards. Interested parties must submit a solution summary, though no funding is provided for this initial submission. [1][5]
Key points
Proposals must apply to the BRAINS Exploratory Topic [1]
Deliverables must include quantitative metrics [3]
Watch items
Resubmissions are permitted in the second intake [4]
Animal use proposals require IACUC review plans [2]
Sources
BRAINS_ISO_ARPA-H-SOL-26-148+Amendment+1.pdfA submission may be deemed non-conforming under this ISO if it fails to meet one or more of the following solicitation requirements: • The proposed concept is applicable to the BRAINS Exploratory Topic. • The proposers meet the eligibility requirements. • The submission meets the submission requirements. • The submission meets the content and formatting requirements in the attached instructions. • The proposer’s concept has not already received funding or been selected for award negotiations for another funding opportunity (whether from ARPA-H or another Government agency).
BRAINS_ISO_ARPA-H-SOL-26-148+Amendment+1.pdfFor all proposed research anticipating animal use, proposals should briefly describe plans for IACUC review and approval.] 6.5 ELECTRONIC INVOICING AND PAYMENTS Performers will be required to register in, and submit invoices for payment through, the Payment Management Services (PMS) Performers will be required to register in, and submit invoices for payment through, the Payment Management Services (PMS) at https://pms.psc.gov Invoices must include a justification (limited to 1,000 characters) such as the following, due to the requirement for government approval in the Defend the Spend (DTS) System: The payment is justified for the BRAINS program to [include the purpose of the project] for Mil
BRAINS_ISO_ARPA-H-SOL-26-148+Amendment+1.pdfInclude quantitative metrics. • A definition of all deliverables (e.g., data, reports, software) to be provided to the Government in support of the proposed tasks/subtasks.
Generated from the public notice and source-backed solicitation passages. Confirm important requirements in the cited brief and official documents.
Public-source intelligence
Source-backed opportunity brief
8 citations · 6 sources
A submission may be deemed non-conforming under this ISO if it fails to meet one or more of the following solicitation requirements: • The proposed concept is applicable to the BRAINS Exploratory Topic. • The proposers meet the eligibility requirements. • The submission meets the submission requirements. • The submission meets the content and formatting requirements in the attached instructions. • The proposer’s concept has not already received funding or been selected for award negotiations for another funding opportunity (whether from ARPA-H or another Government agency).
For all proposed research anticipating animal use, proposals should briefly describe plans for IACUC review and approval.] 6.5 ELECTRONIC INVOICING AND PAYMENTS Performers will be required to register in, and submit invoices for payment through, the Payment Management Services (PMS) Performers will be required to register in, and submit invoices for payment through, the Payment Management Services (PMS) at https://pms.psc.gov Invoices must include a justification (limited to 1,000 characters) such as the following, due to the requirement for government approval in the Defend the Spend (DTS) System: The payment is justified for the BRAINS program to [include the purpose of the project] for Milestones (s) (or TDD tasks/references) [xx] that were accepted by the Program Manager on [date]. https://pms.psc.gov.
Include quantitative metrics. • A definition of all deliverables (e.g., data, reports, software) to be provided to the Government in support of the proposed tasks/subtasks.
Extracted from the official notice and archived solicitation files. Confirm controlling requirements in the source documents.
Notice information
Read full notice text
June 23, 2026: The purpose of Amendment #1 is to update ISO Section 5.4.4 CRITERIA 4: ASSESSMENT OF PROPOSED COST/PRICE. All other terms and conditions remain unchanged. The Advanced Research Projects Agency for Health (ARPA-H) posts this funding opportunity in support of the Brain Repair of Any Injured Neural Structure (BRAINS) Exploratory Topic program. ARPA-H anticipates multiple awards with Other Transaction award types resulting from this announcement. Interested parties are invited to review the Innovative Solutions Opening (ISO) ARPA-H-SOL-26-148. Parties interested in submitting a proposal in response to the ARPA-H BRAINS ISO are required (mandatory) to submit a solution summary. No awards will be made, or funding provided as a result of a solution summary submission. Intake Group 1: Solution Summaries Due: July 9th, 2026, 5:00 PM Full Proposals Due: August 6th, 2026, 5:00PM Intake Group 2: Solution Summaries Due: January 7th, 2027, 5:00 PM Full Proposals Due: February 6th, 2027, 5:00PM
What changed
Jul 2, 2026 · 2 fields changed
DescriptionThe Advanced Research Projects Agency for Health (ARPA-H) posts this funding opportunity in support of the Brain Repair of Any Injured Neural Structure (BRAINS) Exploratory Topic program. ARPA-H anticipates multiple awards with Other Transaction award types resulting from this announcement. Interested parties are invited to review the Innovative Solutions Opening (ISO) ARPA-H-SOL-26-148. Parties interested in submitting a proposal in response to the ARPA-H BRAINS ISO are required (mandatory) to submit a solution summary. No awards will be made, or funding provided as a result of a solution summary submission. Intake Group 1: Solution Summaries Due: July 9th, 2026, 5:00 PM Full Proposals Due: August 6th, 2026, 5:00PM Intake Group 2: Solution Summaries Due: January 7th, 2027, 5:00 PM Full Proposals Due: February 6th, 2027, 5:00PMJune 23, 2026: The purpose of Amendment #1 is to update ISO Section 5.4.4 CRITERIA 4: ASSESSMENT OF PROPOSED COST/PRICE. All other terms and conditions remain unchanged. The Advanced Research Projects Agency for Health (ARPA-H) posts this funding opportunity in support of the Brain Repair of Any Injured Neural Structure (BRAINS) Exploratory Topic program. ARPA-H anticipates multiple awards with Other Transaction award types resulting from this announcement. Interested parties are invited to review the Innovative Solutions Opening (ISO) ARPA-H-SOL-26-148. Parties interested in submitting a proposal in response to the ARPA-H BRAINS ISO are required (mandatory) to submit a solution summary. No awards will be made, or funding provided as a result of a solution summary submission. Intake Group 1: Solution Summaries Due: July 9th, 2026, 5:00 PM Full Proposals Due: August 6th, 2026, 5:00PM Intake Group 2: Solution Summaries Due: January 7th, 2027, 5:00 PM Full Proposals Due: February 6th, 2027, 5:00PMDocuments23
Jun 8, 2026 · 1 field changed
DocumentsNot previously reported2
Notice history
Solicitation · LatestPosted Jul 2, 2026 · response deadline Feb 26, 2027, 10:00 PM UTC
SolicitationPosted Jun 8, 2026 · response deadline Feb 26, 2027, 10:00 PM UTC
SolicitationPosted Jun 8, 2026 · response deadline Feb 26, 2027, 10:00 PM UTC
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