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OpenSolicitation

Selective Harnessing of Intrinsic Neuroplasticity Engineering (SHINE)

Solicitation numberDARPA-PA-25-07-06

DEPT OF DEFENSE · DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA) · DEF ADVANCED RESEARCH PROJECTS AGCY

NAICS 541715 · Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)PSC AC11 · National Defense R&D Services; Department Of Defense - Military; Basic Research
View opportunity on SAM.gov ↗
Response deadlineOct 9, 2026, 4:00 PM UTC
Deadline status36 days remaining
PostedAug 28, 2026
Record refreshedSep 2, 2026

Opportunity summary

Source-cited

DARPA is seeking innovative basic or applied research concepts in targeted neuroplasticity via a Disruption Opportunity (DO) under DARPA-PA-25-07. Awards will be made as an Other Transaction (OT) for Prototype Agreement, limited to $2,000,000 per award. [1][4]

Key points

  • Scope is a proof-of-concept effort, not a comprehensive program. [1]
  • Response deadline is October 9, 2026. [4]

Watch items

  • Proposals must include IRB/IACUC submission verification. [3]
  • Proposers must host a site visit around Month 8-10. [2]

Sources

  1. DARPA-PA-25-07-06.pdfSHINE is intentionally scoped as a proof-of-concept effort rather than a comprehensive neuroplasticity program.
  2. DARPA-PA-25-07-06.pdfDARPA-PA-25-07-06 All proposals must include the following meetings and travel in the proposed schedule and costs: • To foster collaboration between teams and disseminate program developments, a two-day virtual Principal Investigator (PI) meeting will be held at approximately Month 9. • Regular teleconference meetings will be scheduled with the Government team for progress reporting and problem identification and mitigation. • Proposers must anticipate hosting one site visit by the DARPA Program Manager at approximately Month 8-10 to execute an in-person technical demonstration of progress towards milestones. • Conference and publication costs should not be included.
  3. DARPA-PA-25-07-06.pdfProposer must verify in their technical proposal that their protocol has been submitted to their local IRB (for HSR) or IACUC (for Animal Use) as appropriate for their chosen testing model and prior to proposal submission.
  4. Official SAM.gov noticePosted Aug 28, 2026; Responses due Oct 9, 2026, 4:00 PM UTC; Archive date Nov 8, 2026

Generated from the public notice and source-backed solicitation passages. Confirm important requirements in the cited brief and official documents.

Public-source intelligence

Source-backed opportunity brief

6 citations · 6 sources

The CMMC Program provides a consistent methodology to assess a defense contractor's implementation of required cybersecurity requirements.

[1] DARPA-PA-25-07-06.pdf

Scope

SHINE is intentionally scoped as a proof-of-concept effort rather than a comprehensive neuroplasticity program.

[1] DARPA-PA-25-07-06.pdf

Deliverables

DARPA-PA-25-07-06 All proposals must include the following meetings and travel in the proposed schedule and costs: • To foster collaboration between teams and disseminate program developments, a two-day virtual Principal Investigator (PI) meeting will be held at approximately Month 9. • Regular teleconference meetings will be scheduled with the Government team for progress reporting and problem identification and mitigation. • Proposers must anticipate hosting one site visit by the DARPA Program Manager at approximately Month 8-10 to execute an in-person technical demonstration of progress towards milestones. • Conference and publication costs should not be included.

[1] DARPA-PA-25-07-06.pdf

Evaluation

Proposal Evaluation and Selection Proposals will be evaluated and selected in accordance with Section 6 of DARPA-PA-25-07 Amendment 1.

[1] DARPA-PA-25-07-06.pdf

Submission

Proposer must verify in their technical proposal that their protocol has been submitted to their local IRB (for HSR) or IACUC (for Animal Use) as appropriate for their chosen testing model and prior to proposal submission.

[1] DARPA-PA-25-07-06.pdf

Extracted from the official notice and archived solicitation files. Confirm controlling requirements in the source documents.

Notice information

Read full notice text

The Defense Advanced Research Projects Agency (DARPA) Defense Sciences Office (DSO) is issuing a Disruption Opportunity (DO), inviting submissions of innovative basic or applied research concepts in the technical domain of targeted neuroplasticity. This DO is issued under the Program Announcement for Disruptioneering, DARPA-PA-25-07 Amendment 1. All awards will be made in the form of an Other Transaction (OT) for Prototype Agreement. The total award value for this DO is limited to $2,000,000 per award. This total award value includes Government funding and performer cost share if required or proposed.

What changed

No field-level changes were detected between related notices.

Notice history

Attachments

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