Response deadlineOct 19, 2026, 4:00 PM UTC
Deadline status46 days remaining
PostedAug 21, 2026
Record refreshedSep 2, 2026
Opportunity summary
Source-citedDARPA seeks proposals for Protein ENGineering (PENG) to create a universal, software-defined platform for precise, programmable editing of endogenous proteins. This integrated platform must be validated in high-fidelity cellular models to achieve tissue-level proof-of-concept. [1]
Key points
- Goal is a universal, software-defined proteome engineering platform. [1]
- Performers must integrate novel techniques for endogenous protein modification. [1]
Watch items
- Abstract submission is required to be considered for full proposal. [2]
- Response deadline is October 19, 2026. [3]
Sources
- Attachment_E_Proposal_Instructions_and_Volume_II_Template_Cost.docx
Email messages must include “Subawardee Cost Proposal” in the subject line and identify the principal investigator, prime proposer organization, and proposal title in the body of the message. **COVER SHEET** **[PRIME ORGANIZATION LOGO]** | | | | --- | --- | | Proposal **Title** | | | Proposer Organization | | | Type of Organization | Choose all that apply: Large Business, Small Disadvantaged Business, Other Small Business, HBCU, MI, Other Educational, or Other Nonprofit. | | Proposer Reference Number, if any | | | Technical Point of Contact (POC) | Name: Address: Telephone: Email: | | Administrative POC | Name: Address: Telephone: Email: | | Place(s) of Performance | | | Period(s) of Perform
- DARPA-PS-26-129-Amendment-01.pdf
Proposers are required to submit an abstract to DARPA to be considered for full proposal package submission.
- Official SAM.gov notice
Posted Aug 21, 2026; Responses due Oct 19, 2026, 4:00 PM UTC; Archive date Nov 18, 2026
Generated from the public notice and source-backed solicitation passages. Confirm important requirements in the cited brief and official documents.
Public-source intelligence
Source-backed opportunity brief
Email messages must include “Subawardee Cost Proposal” in the subject line and identify the principal investigator, prime proposer organization, and proposal title in the body of the message. **COVER SHEET** **[PRIME ORGANIZATION LOGO]** | | | | --- | --- | | Proposal **Title** | | | Proposer Organization | | | Type of Organization | Choose all that apply: Large Business, Small Disadvantaged Business, Other Small Business, HBCU, MI, Other Educational, or Other Nonprofit. | | Proposer Reference Number, if any | | | Technical Point of Contact (POC) | Name: Address: Telephone: Email: | | Administrative POC | Name: Address: Telephone: Email: | | Place(s) of Performance | | | Period(s) of Performance | | | Months | | | Other Team Members **(subawardees and consultants), if any** | Technical POC Name: Organization: Organization Type: | | **Total Proposed Cost (by Contractor Fiscal Year)** | Year 1: $ Year 2: $ Year 3: $ Year 4: $ Total: $ | | **SAM.gov Unique Entity ID (UEI)[[1]](#endnote-1)** | | | **Taxpayer identification number (TIN)[[2]](#endnote-2)** | | | **Commercial and Government Entity (CAGE) code[[3]](#endnote-3)** | | | **Administration Office POC at Defense Contract Management Agency (DCMA)[[4]](#endnote-4) or Office of Naval Research (ONR)[[5]](#endnote-5), if known** | Name: Address: Telephone: | | **Audit Office POC at Defense Contract Audit Agency (DCAA)[[6]](#endnote-6), if known** | Name: Address: Telephone: | | Date Proposal was Prepared | | | Proposal Validity Period (minimum 120 days) | | Table of Contents [Cost Summary 3](#_Toc103003678) [Cost Details 3](#_Toc103003679) [**1.** **Direct Labor** 3](#_Toc103003680) [**2.** **Indirect Costs** 3](#_Toc103003681) [**3.** **Materials** 3](#_Toc103003682) [**4.** **Equipment Purchases** 3](#_Toc103003683) [**5.** **Travel** 3](#_Toc103003684) [**6.** **Other Direct Costs (ODCs)** 4](#_Toc103003685) [**7.** **Cost Sharing** 4](#_Toc103003686) [**8.** **Consultant Costs** 4](#_Toc103003687) [**9.** **Subawardee Costs** 4](#_Toc103003688) [**10.** **Rate Agreements** 4](#_Toc103003689) [**11.** **Requirements for proposers requesting a procurement contract** 4](#_Toc103003690) [**12.** **Requirements for proposers requesting an Other Transaction for Prototypes** 5](#_Toc103003691) # Cost Summary [Provide the following cost summary information:
Scope
Note that by signing this Agreement, *(INSERT COMPANY NAME)* also attests to the accuracy and completion of the Certifications of the Agreement herein Attachment 5, Certifications for Agreement. *(REMOVE LAST SENTENCE IF REPS/CERTS IS NOT INCLUDED AS ATTACHMENT AND IS INSTEAD SIGNED AND ON FILE SEPARATELY)* FOR (*INSERT COMPANY NAME*) FOR THE GOVERNMENT DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (Signature) (Signature) (Name, Title) (Date) (Name, Title) (Date) **TABLE OF CONTENTS** **ARTICLES** ARTICLE I Scope of the Agreement ARTICLE II Term ARTICLE III Management of the Project ARTICLE IV Agreement Administration ARTICLE V Obligation and Payment ARTICLE VI Disputes ARTICLE VII Patent Rights ARTICLE VIII Data Rights ARTICLE IX Foreign Access to Technology ARTICLE X Safeguarding Covered Defense Information and Cyber Incident Reporting ARTICLE XI Follow-On Production Contracts or Other Transactions ARTICLE XII Title to and Disposition of Property ARTICLE XIII Civil Rights Act ARTICLE XIV Security ARTICLE XV Public Release or Dissemination of Information ARTICLE XVI Order of Precedence ARTICLE XVII Execution ARTICLE XVIII Prohibition on Contracting for Certain Telecommunications and Video Surveillance Services or Equipment **ATTACHMENTS** ATTACHMENT 1 Task Description Document ATTACHMENT 2 Report Requirements ATTACHMENT 3 Schedule of Milestones and Payments ATTACHMENT 4 Agreements Officer’s Representative Appointment Memo ATTACHMENT 5 Certifications for Agreement ATTACHMENT 6 Property/Equipment **ARTICLE I: SCOPE OF THE AGREEMENT** **A.
Deliverables
The Performer shall insert the substance of this clause, including this Paragraph (e) and excluding Paragraph (b)(2), in all subcontracts and other contractual instruments, including subcontracts for the acquisition of commercial items. (End of article) **ATTACHMENT 1:** **TASK DESCRIPTION DOCUMENT** **(Including Initial Program Plan)** Task 1: **ATTACHMENT 2:** **REPORT REQUIREMENTS** This agreement will utilize the DARPA VAULT website for electronically uploading **all required reports listed below and data deliverables in Attachment 3, Schedule of Milestones and Payments**.
Evaluation
DARPA will review all conforming abstracts using the evaluation criteria published in the solicitation.
Submission
Proposers are required to submit an abstract to DARPA to be considered for full proposal package submission.
Key dates
Posted Aug 21, 2026; Responses due Oct 19, 2026, 4:00 PM UTC; Archive date Nov 18, 2026
Extracted from the official notice and archived solicitation files. Confirm controlling requirements in the source documents.